Natural anti-obesity agents and their therapeutic role in management of obesity: A future trend perspective

Biomed Pharmacother. 2019 Feb:110:224-238. doi: 10.1016/j.biopha.2018.11.076. Epub 2018 Nov 24.

Abstract

In the present scenario, obesity is a challenging health problem and its prevalence along with comorbidities are on the rise around the world. According to world health organization and organisation for economic co-operation and development epidemiology reports, overweight and obesity are the fifth foremost causes of deaths globally. The increasing rate of obesity is becoming a mammoth problem which enormously affects an individual's quality of life. The conventional therapy of obesity mainly involves synthetic moieties and surgical procedures, which has many harmful side effects and chances of recurrence with severity. Hence, the Present review is a metanalysis of all the available data on the use of the plants with their biological source, active phytochemical constituents and a probable mechanism of action as natural anti-obesity agents. The metanalysis of data during the period of 2000-2018 was performed with the help of scientific data search engine National Center for Biotechnology Information (NCBI/PubMed). This data reveals the need and scope of further research in the development of new natural phytoconstituents for the management of obesity.

Keywords: Management; Mechanism; Natural products; Obesity; Phytoconstituents.

Publication types

  • Review

MeSH terms

  • Anti-Obesity Agents / isolation & purification
  • Anti-Obesity Agents / therapeutic use*
  • Biological Products / isolation & purification
  • Biological Products / therapeutic use
  • Disease Management*
  • Flavonoids / isolation & purification
  • Flavonoids / therapeutic use
  • Forecasting
  • Humans
  • Obesity / drug therapy*
  • Obesity / metabolism
  • Phytochemicals / isolation & purification
  • Phytochemicals / therapeutic use*
  • Plant Extracts / isolation & purification
  • Plant Extracts / therapeutic use*

Substances

  • Anti-Obesity Agents
  • Biological Products
  • Flavonoids
  • Phytochemicals
  • Plant Extracts