Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Dora Abraham; Janos Feher; Gian Luca Scuderi; Dora Szabo; Arpad Dobolyi; Melinda Cservenak; Janos Juhasz; Balazs Ligeti; Sandor Pongor; Mari Carmen Gomez-Cabrera; Jose Vina; Mitsuru Higuchi; Katsuhiro Suzuki; Istvan Boldogh; Zsolt Radak

doi:10.1016/j.exger.2018.12.005

Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome

Exp Gerontol. 2019 Jan:115:122-131. doi: 10.1016/j.exger.2018.12.005. Epub 2018 Dec 6.

Authors

Affiliations

¹ Research Institute of Sport Science, University of Physical Education, Budapest, Hungary.
² Ophthalmology Unit, NESMOS Department, Sant'Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome, Italy.
³ Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary.
⁴ MTA-ELTE Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Eötvös Loránd University, 1117 Budapest, Hungary.
⁵ Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
⁶ Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary; Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
⁷ Department of Physiology, Faculty of Medicine, University of Valencia, Spain.
⁸ Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan.
⁹ Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, USA.
¹⁰ Research Institute of Sport Science, University of Physical Education, Budapest, Hungary; Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama, Japan. Electronic address: radak@tf.hu.

PMID: 30529024
DOI: 10.1016/j.exger.2018.12.005

Abstract

It has been suggested that exercise training and probiotic supplementation could decelerate the progress of functional and biochemical deterioration in APP/PS1 transgenic mice (APP/PS1^TG). APP/PS1^TG mice were subjected to exercise training and probiotic treatments and functional, biochemical and microbiome markers were analyzed. Under these conditions the mice significantly outperformed controls on The Morris Maze Test, and the number of beta-amyloid plaques decreased in the hippocampus. B. thetaiotaomicron levels correlated highly with the results of the Morris Maze Test (p < 0.05), and this group of bacteria was significantly elevated in the microbiome of the APP/PS1^TG mice compared to the wild type. L. johnsonii levels positively correlated with the beta amyloid content and area. Data revealed that exercise and probiotic treatment can decrease the progress of Alzheimer's Disease and the beneficial effects could be partly mediated by alteration of the microbiome.

Keywords: Alzheimer; Exercise; Microbiome; Probiotics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / microbiology
Alzheimer Disease / therapy*
Amyloid beta-Peptides / metabolism
Amyloid beta-Protein Precursor / genetics*
Amyloid beta-Protein Precursor / metabolism
Animals
Disease Models, Animal
Hippocampus / metabolism*
Male
Mice
Mice, Transgenic
Microbiota*
Physical Conditioning, Animal / methods*
Plaque, Amyloid / pathology
Presenilin-1
Probiotics / administration & dosage*

Substances

Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Presenilin-1