Predictive value of platelet-to-lymphocyte ratio in patients with sarcoidosis

Biomark Med. 2019 Feb;13(3):197-204. doi: 10.2217/bmm-2018-0252. Epub 2019 Jan 3.

Abstract

Aim: We aimed to evaluate platelet-to-lymphocyte ratio (PLR) in patients with sarcoidosis.

Methods: A total of 310 sarcoidosis patients and 220 healthy controls retrospectively were recorded in this study.

Results: PLR was significantly higher in patients with sarcoidosis than in the control group, and was also significantly higher in patients with pulmonary involvement in stage 2-3-4 than in stage 1. PLR were significantly positive correlated with erythrocyte sedimentation rate. The cut-off values for PLR for predicting a sarcoidosis diagnosis were determined as 158.

Conclusion: Increase in PLR value can be used for guiding both the diagnosis of sarcoidosis and the involvement of parenchyma.

Keywords: biomarker; platelet-to-lymphocyte ratio; sarcoidosis.

MeSH terms

  • Adult
  • Biomarkers / blood*
  • Blood Platelets / pathology*
  • Blood Sedimentation
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphocytes / pathology*
  • Male
  • Middle Aged
  • Prognosis
  • ROC Curve
  • Retrospective Studies
  • Sarcoidosis / blood*
  • Sarcoidosis / diagnosis*

Substances

  • Biomarkers