Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure

J Neuroimmunol. 2019 Feb 15:327:36-40. doi: 10.1016/j.jneuroim.2019.01.009. Epub 2019 Jan 17.

Abstract

Demyelination, axonal loss and failure of tissue repair characterize MS lesions. Bone morphogenetic proteins (BMPs) signaling is associated with remyelination failure. Coco is one of the BMP antagonists. We found reduced Coco serum levels in relapsing-remitting MS (RR-MS) and primary progressive MS (PP-MS) patients compared to matched healthy controls (HC) and patients with rheumatoid arthritis. Exposure of P19 cells, in the presence of retinoic acid, BMP-2, or BMP-4 to Coco, at average sera level of MS patients failed to induce neuronal phenotype, in contrast to the average sera level of HC. Coco may be a player in the BMP dysregulation and the tissue repair failure in MS.

Keywords: Bone morphogenetic proteins; Coco; Multiple sclerosis; Oligodendrocytes precursor cells (OPCs); Oligodendrogenesis; P19 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bone Morphogenetic Protein 2 / metabolism
  • Bone Morphogenetic Protein 4 / metabolism
  • Female
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / blood*
  • Nerve Regeneration / physiology

Substances

  • BMP2 protein, human
  • BMP4 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 4
  • DAND5 protein, human
  • Intercellular Signaling Peptides and Proteins