Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Takako Miyamura; Hiroshi Moritake; Hideki Nakayama; Shiro Tanaka; Daisuke Tomizawa; Norio Shiba; Akiko M Saito; Akio Tawa; Akira Shimada; Shotaro Iwamoto; Yasuhide Hayashi; Takashi Koike; Keizo Horibe; Atsushi Manabe; Shuki Mizutani; Takashi Taga; Souichi Adachi

doi:10.1111/bjh.15799

Clinical and biological features of paediatric acute myeloid leukaemia (AML) with primary induction failure in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

Br J Haematol. 2019 Apr;185(2):284-288. doi: 10.1111/bjh.15799. Epub 2019 Feb 19.

Authors

Takako Miyamura^{1

2}, Hiroshi Moritake³, Hideki Nakayama⁴, Shiro Tanaka⁵, Daisuke Tomizawa⁶, Norio Shiba⁷, Akiko M Saito², Akio Tawa⁸, Akira Shimada⁹, Shotaro Iwamoto¹⁰, Yasuhide Hayashi¹¹, Takashi Koike¹², Keizo Horibe², Atsushi Manabe¹³, Shuki Mizutani¹⁴, Takashi Taga¹⁵, Souichi Adachi¹⁶

Affiliations

¹ Department of Paediatrics, Osaka University Graduate School of Medicine, Osaka, Japan.
² Clinical Research Centre, National Hospital Organization Nagoya Medical Centre, Aichi, Japan.
³ Division of Paediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
⁴ Department of Paediatrics, National Hospital Organization, Kyusyu Cancer Centre, Fukuoka, Japan.
⁵ Department of Clinical Biostatistics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
⁶ Division of Leukaemia and Lymphoma, Children's Cancer Centre, National Centre for Child Health and Development, Tokyo, Japan.
⁷ Department of Paediatrics, Yokohama City University School of Medicine, Yokohama, Japan.
⁸ Department of Paediatrics, Osaka National Hospital, Osaka, Japan.
⁹ Department of Paediatrics, Okayama University Graduate School of Medicine, Okayama, Japan.
¹⁰ Department of Paediatrics, Mie University Graduate School of Medicine, Tsu, Japan.
¹¹ Department of Haematology/Oncology, Gunma Children's Medical Centre, Shibukawa, Japan.
¹² Department of Paediatrics, Tokai University School of Medicine, Isehara, Japan.
¹³ Department of Paediatrics, St. Luke's International Hospital, Tokyo, Japan.
¹⁴ Department of Paediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
¹⁵ Department of Paediatrics, Shiga University of Medical Science, Shiga, Japan.
¹⁶ Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

PMID: 30784060
DOI: 10.1111/bjh.15799

Abstract

The prognosis of paediatric acute myeloid leukaemia (AML) with primary induction failure (PIF) is extremely poor, and effective treatment strategies have not been established. We investigated the clinical and biological features of paediatric AML patients with PIF registered to the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. The 3-year overall survival rate of the 41 PIF patients was 19.0%. High leucocyte count, M7 morphology, and unfavourable genetic aberrations, such as FLT3-internal tandem duplication, NUP98-NSD1 and high MECOM or PRDM16 expression, were risk factors for PIF. More effective treatment strategies based on leukaemia biology need to be urgently explored.

Keywords: acute myeloid leukaemia; childhood; genetic alteration; haematopoietic stem cell transplantation; primary induction failure.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Antineoplastic Agents / therapeutic use
Child
Child, Preschool
Chromosome Aberrations
Chromosome Duplication
Female
Genetic Predisposition to Disease
Hematopoietic Stem Cell Transplantation
Humans
Induction Chemotherapy / methods*
Infant
Infant, Newborn
Japan / epidemiology
Leukemia, Myeloid, Acute / drug therapy*
Leukemia, Myeloid, Acute / genetics
Leukemia, Myeloid, Acute / mortality
Leukocyte Count
Male
Prognosis
Remission Induction
Retrospective Studies
Risk Factors
Survival Analysis
Treatment Failure

Substances

Antineoplastic Agents