Chemical constituents of the trunks and roots of Thuja sutchuenensis

Xueying Guo; Miaomiao Wang; Jiafeng Wu; Guiyun Wu; Xiao Zhang; Luqiong Huo; Hongxin Liu; Yihong Chen; Guowen Xie; Haibo Tan; Sheng-Xiang Qiu

doi:10.1016/j.fitote.2019.02.025

Chemical constituents of the trunks and roots of Thuja sutchuenensis

Fitoterapia. 2019 Apr:134:264-269. doi: 10.1016/j.fitote.2019.02.025. Epub 2019 Feb 27.

Authors

Xueying Guo¹, Miaomiao Wang², Jiafeng Wu³, Guiyun Wu³, Xiao Zhang³, Luqiong Huo², Hongxin Liu⁴, Yihong Chen⁵, Guowen Xie⁶, Haibo Tan⁷, Sheng-Xiang Qiu⁸

Affiliations

¹ School of Life Sciences, Guangzhou University, Guangzhou 510006, People's Republic of China; Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China.
² Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
³ Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China.
⁴ Guangdong Institute of Microbiology, Guangzhou 510070, People's Republic of China.
⁵ Guangzhou Green Health Biotechnology Co., Ltd., Guangzhou, People's Republic of China.
⁶ School of Life Sciences, Guangzhou University, Guangzhou 510006, People's Republic of China. Electronic address: xieguowen126@126.com.
⁷ Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China. Electronic address: tanhaibo@scbg.ac.cn.
⁸ Program of Natural Product Medicinal Chemistry, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China. Electronic address: sxqiu@scbg.ac.cn.

PMID: 30825577
DOI: 10.1016/j.fitote.2019.02.025

Abstract

Five new compounds including two stilbenes, designated thujasutchins A (1) and B (2), two phenolic compounds namely thujasutchins C (3) and D (4), as well as one sesquiterpene thujasutchin E (5), were isolated from the 95% ethanolic extract from the trunks and roots of Thuja sutchuenensis. Their structures were determined by means of extensively spectroscopic analysis including UV, IR, HRESIMS, ¹H and ¹³C NMR (COSY, HSQC, HMBC). Moreover, compounds 1, 3-5 were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines.

Keywords: Chemical constituents; Cytotoxic activity; Sesquiterpene; Stilbenes; Thuja sutchuenensis.

MeSH terms

Cell Line, Tumor
China
Humans
Molecular Structure
Phytochemicals / chemistry
Phytochemicals / isolation & purification
Plant Roots / chemistry
Sesquiterpenes / chemistry*
Sesquiterpenes / isolation & purification
Stilbenes / chemistry*
Stilbenes / isolation & purification
Thuja / chemistry*

Substances

Phytochemicals
Sesquiterpenes
Stilbenes