Cellular functions of long noncoding RNAs

Nat Cell Biol. 2019 May;21(5):542-551. doi: 10.1038/s41556-019-0311-8. Epub 2019 May 2.

Abstract

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena / genetics*
  • Gene Regulatory Networks / genetics
  • Genome / genetics*
  • Humans
  • Protein Biosynthesis / genetics*
  • Protein Processing, Post-Translational / genetics
  • RNA Stability / genetics
  • RNA, Long Noncoding / genetics*

Substances

  • RNA, Long Noncoding