Papillary meningioma: Diagnosis by intraoperative crush smear cytology

Diagn Cytopathol. 2019 Sep;47(9):907-911. doi: 10.1002/dc.24201. Epub 2019 May 10.

Abstract

Papillary meningioma is a rare, aggressive variant of meningioma. It accounts for less than 1% of all meningiomas. It is categorized as WHO grade III due to high rate of recurrence and metastasis. Histopathologic features of papillary meningioma are well described, but cytomorphology is rarely been described. We report a case of papillary meningioma, diagnosed on intraoperative crush cytology and later confirmed on histopathology. Papillary meningioma possesses characteristic cytological features. Along with the cellular meningothelial features, radial arrangement of cells around thin and thick walled hyalinised blood vessels gives the diagnostic clue. In addition, knowledge of clinical and radiological features is extremely helpful to arrive at the correct diagnosis and to differentiate it from other papillary lesions involving central nervous system. Due to aggressive clinical course and poor prognosis of papillary meningioma, a timely recognition of the diagnosis is desirable and helpful for rationalizing approaches to therapy.

Keywords: aggressive; differential diagnosis; intraoperative crush cytology; papillary meningioma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cytodiagnosis*
  • Female
  • Humans
  • Intraoperative Care*
  • Magnetic Resonance Imaging*
  • Meningeal Neoplasms* / diagnostic imaging
  • Meningeal Neoplasms* / pathology
  • Meningeal Neoplasms* / surgery
  • Meningioma* / diagnostic imaging
  • Meningioma* / pathology
  • Meningioma* / surgery