Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Curtis C Hughey; Peter A Crawford

doi:10.1016/j.cmet.2019.05.013

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Cell Metab. 2019 Jun 4;29(6):1236-1238. doi: 10.1016/j.cmet.2019.05.013.

Authors

Curtis C Hughey¹, Peter A Crawford²

Affiliations

¹ Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: chughey@umn.edu.
² Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: crawforp@umn.edu.

PMID: 31167118
DOI: 10.1016/j.cmet.2019.05.013

Abstract

Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Antioxidants
Citric Acid Cycle*
Gluconeogenesis
Liver
Oxidation-Reduction
Pyruvate Carboxylase*
Pyruvates

Substances

Antioxidants
Pyruvates
Pyruvate Carboxylase