Ag and Au nanoparticles/reduced graphene oxide composite materials: Synthesis and application in diagnostics and therapeutics

The exceptional electrical, thermal, optical and mechanical properties have made two dimensional sp² hybridized graphene a material of choice in both academic as well as industrial research. In the last few years, researchers have devoted their efforts towards the development of graphene/polymer, graphene/metal nanoparticle and graphene/ceramic nanocomposites. These materials display excellent mechanical, electrical, thermal, catalytic, magnetic and optical properties which cannot be obtained separately from the individual components. Fascinating physical and chemical properties are displayed by noble metal nanomaterials and thus they represent model building blocks for modifying nanoscale structures for diverse applications extending from catalysis, optics to nanomedicine. Insertion of noble metal (Au, Ag) nanoparticles (NPs) into chemically derived graphene is thus of primary importance to open new avenues for both materials in various fields where the specific properties of each material act synergistically to provide hybrid materials with exceptional performances. This review attempts to summarize the different synthetic procedures for the preparation of Ag and Au NPs/reduced graphene oxide (rGO) composites. The synthesis processes of metal NPs/rGO composites are categorised into in-situ and ex-situ techniques. The in-situ approach consists of simultaneous reduction of metal salts and GO to obtain metal NPs/rGO nanocomposite materials, while in the ex-situ process, the metal NPs of desired size and shape are first synthesized and then transferred onto the GO or rGO matrix. The application of the Ag NPs and Au NPs/rGO composite materials in the area of biomedical (drug delivery and photothermal therapy) and biosensing are the focus of this review article.