High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells

Blood Adv. 2019 Aug 13;3(15):2323-2327. doi: 10.1182/bloodadvances.2019032169.

Yuji Takihara¹, Ayako Nakamura-Ishizu^{1

2}, Darren Qiancheng Tan¹, Masahiro Fukuda^{2

3}, Takayoshi Matsumura¹, Mitsuhiro Endoh^{1

4}, Yuichiro Arima^{2

5}, Desmond Wai Loon Chin⁶, Terumasa Umemoto², Michihiro Hashimoto², Hidenobu Mizuno², Toshio Suda^{1

2}

¹ Cancer Science Institute of Singapore, National University of Singapore, Singapore.
² International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan.
³ Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore.
⁴ Department of Pluripotent Stem Cell Biology, Institute of Molecular Embryology and Genetics, and.
⁵ Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; and.
⁶ Genome Institute of Singapore, Singapore.

Abstract

HSCs can be separated based on high or low mitochondrial mass.
Higher mitochondrial mass is associated with quiescence and greater reconstitution capacity of HSCs.