Sonochemical synthesis and fabrication of honeycomb like zirconium dioxide with chitosan modified electrode for sensitive electrochemical determination of anti-tuberculosis (TB) drug

Tse-Wei Chen; Airathevar Sivasamy Vasantha; Shen-Ming Chen; Dunia A Al Farraj; Mohamed Soliman Elshikh; Roua M Alkufeidy; Manal M Al Khulaifi

doi:10.1016/j.ultsonch.2019.104718

Sonochemical synthesis and fabrication of honeycomb like zirconium dioxide with chitosan modified electrode for sensitive electrochemical determination of anti-tuberculosis (TB) drug

Ultrason Sonochem. 2019 Dec:59:104718. doi: 10.1016/j.ultsonch.2019.104718. Epub 2019 Aug 1.

Authors

Tse-Wei Chen¹, Airathevar Sivasamy Vasantha², Shen-Ming Chen³, Dunia A Al Farraj⁴, Mohamed Soliman Elshikh⁵, Roua M Alkufeidy⁵, Manal M Al Khulaifi⁵

Affiliations

¹ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan; Research and Development Center for Smart Textile Technology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
² Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
³ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan. Electronic address: smchen78@ms15.hinet.net.
⁴ Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. Electronic address: dfarrj@ksu.edu.sa.
⁵ Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

PMID: 31442770
DOI: 10.1016/j.ultsonch.2019.104718

Abstract

Herein, novel honeycomb like zirconium dioxide with chitosan (ZrO₂@chitosan) nanocomposite have been designed through a facile ultrasound-assisted method and followed by a simple sonication process (bath-type ultrasound washer; Honda Electronics-W-118T; 100 W/cm² and 300 kHz frequency). After then, as-synthesized ZrO₂@chitosan was characterized by FESEM, XRD and EIS. The ZrO₂@chitosan nanocomposite modified glassy carbon electrode shows excellent electrochemical sensing performance towards anti-tuberculosis drug (rifampicin). Furthermore, the ZrO₂@chitosan modified and fabricated electrochemical sensor showed a wide linear range between 0.015 µM and 547.4 µM and nanomolar detection limit (7.5 nM). Moreover, the ZrO₂@chitosan modified electrode showed selectivity towards the detection of anti-tuberculosis drug (rifampicin). The ZrO₂@chitosan nanocomposite film modified non-enzymatic sensor has high stable and good reproducible towards the detection of rifampicin. In addition, the as-synthesized ZrO₂@chitosan nanocomposite modified electrode has been applied to the determination of rifampicin in biological samples such as human serum and urine samples.

Keywords: Anti-tuberculosis drug analysis; Biopolymer; Electrochemical sensor; Sonochemical synthesis; Zirconium dioxide.

MeSH terms

Antitubercular Agents / analysis*
Antitubercular Agents / chemistry
Carbon / chemistry
Chemistry Techniques, Synthetic
Chitosan / chemistry*
Electrochemistry / instrumentation*
Electrodes
Limit of Detection*
Nanocomposites / chemistry*
Nanotechnology
Oxidation-Reduction
Reproducibility of Results
Rifampin / analysis
Rifampin / chemistry
Ultrasonic Waves*
Zirconium / chemistry*

Substances

Antitubercular Agents
Carbon
Chitosan
Zirconium
zirconium oxide
Rifampin