Mixed Actinomyces israelii and Aggregatibacter actinomycetemcomitans infection causing empyema necessitatis and multiple skin abscesses in an immunocompetent patient

BMJ Case Rep. 2019 Sep 24;12(9):e230287. doi: 10.1136/bcr-2019-230287.

Abstract

A 45-year-old- man presented with left chest wall pain, swelling and cough. Over a 2-month period he developed abscesses in the right foot, right anterior thigh, left buttock and left chest. Incision and drainage of the soft tissue abscesses and video-assisted thoracoscopic surgery to drain the loculated empyema contiguous with the chest wall abscess were performed as surgical management. Gram stain showed beaded Gram-positive rods and the culture initially grew Aggregatibacter actinomycetemcomitans and Eikenella corrodens Pathological evaluation of the pleura showed sulfur granules and organisms consistent with Actinomyces spp. on Gomori methenamine silver stain; Actinomyces israelii was recovered in culture with extended incubation. The patient was treated for 3 weeks with ceftriaxone and oral metronidazole, followed by oral amoxicillin. Culture of A. actinomycetemcomitans with other findings consistent with actinomycosis warrants 6-12 months of antibiotic therapy.

Keywords: infectious diseases; surgery.

Publication types

  • Case Reports

MeSH terms

  • Abscess / microbiology*
  • Actinomyces / drug effects
  • Actinomycosis / drug therapy
  • Actinomycosis / microbiology*
  • Aggregatibacter actinomycetemcomitans / drug effects
  • Anti-Bacterial Agents / therapeutic use
  • Chest Pain
  • Coinfection / microbiology
  • Cough
  • Empyema, Pleural / microbiology*
  • Empyema, Pleural / surgery
  • Humans
  • Lung Diseases / microbiology*
  • Male
  • Middle Aged
  • Pasteurellaceae Infections / drug therapy
  • Pasteurellaceae Infections / microbiology*
  • Skin Diseases, Bacterial / drug therapy
  • Skin Diseases, Bacterial / microbiology*

Substances

  • Anti-Bacterial Agents

Supplementary concepts

  • Actinomyces israelii