The neurotransmitter systems of the brain are exposed to dysregulation during alcohol withdrawal. This contributes to the development of the pathological craving for alcohol in which corticotropin-releasing hormone receptors are may be involved. During the period of alcohol withdrawal, the level of CRFR2 mRNA in the ventral tegmental area of the brain on the seventh day of abstinence was significantly increased in comparison with the control group. This supports existing concepts on possible participation in the modulation of dopaminergic and GABA-neural neurons in the ventral tegmental area the brain.
Neĭromediatornye sistemy mozga podverzheny disreguliatsii v period alkogol'noĭ abstinentsii. Éto sposobstvuet razvitiiu sostoianiia patologicheskogo vlecheniia k alkogoliu. Predpolagaetsia, chto v mekhanizm razvitiia tiagi k alkogoliu vovlecheny retseptory kortikoliberina vtorogo tipa (CRFR2). V dannoĭ rabote pokazano, chto v period otmeny alkogolia uroven' mRNK CRFR2 v ventral'noĭ tegmental'noĭ oblasti mozga na sed'mye sutki abstinentsii byl dostoverno uvelichen v sravnenii s gruppoĭ kontrolia, chto svidetel'stvuet v pol'zu vozmozhnogo uchastiia CRFR2 v moduliatsii dofaminergicheskikh i GAMK-ergicheskikh neĭronov v ventral'noĭ tegmental'noĭ oblasti mozga.
Keywords: CRFR2; alcohol withdrawal; prolonged alcoholism; receptors of corticoliberin.