The Role of Non-coding RNAs in Oncology

Frank J Slack; Arul M Chinnaiyan

doi:10.1016/j.cell.2019.10.017

The Role of Non-coding RNAs in Oncology

Cell. 2019 Nov 14;179(5):1033-1055. doi: 10.1016/j.cell.2019.10.017.

Authors

Frank J Slack¹, Arul M Chinnaiyan²

Affiliations

¹ Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address: fslack@bidmc.harvard.edu.
² Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: arul@umich.edu.

Abstract

For decades, research into cancer biology focused on the involvement of protein-coding genes. Only recently was it discovered that an entire class of molecules, termed non-coding RNA (ncRNA), plays key regulatory roles in shaping cellular activity. An explosion of studies into ncRNA biology has since shown that they represent a diverse and prevalent group of RNAs, including both oncogenic molecules and those that work in a tumor suppressive manner. As a result, hundreds of cancer-focused clinical trials involving ncRNAs as novel biomarkers or therapies have begun and these are likely just the beginning.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Clinical Trials as Topic
Humans
Medical Oncology*
Neoplasms / genetics
Oncogenes
RNA, Untranslated / genetics
RNA, Untranslated / metabolism*

Substances

Biomarkers, Tumor
RNA, Untranslated

Abstract

Publication types

MeSH terms

Substances

Grants and funding