A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer

Zeyu Zhang; Yawei Qu; Yu Cao; Xiaojing Shi; Hongbo Guo; Xiaojun Zhang; Sheng Zheng; Haifeng Liu; Zhenhua Hu; Jie Tian

doi:10.1002/jbio.201960152

A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer

J Biophotonics. 2020 Mar;13(3):e201960152. doi: 10.1002/jbio.201960152. Epub 2019 Dec 16.

Authors

Zeyu Zhang^{1

2}, Yawei Qu^{3

4}, Yu Cao⁵, Xiaojing Shi^{2

6}, Hongbo Guo⁷, Xiaojun Zhang⁸, Sheng Zheng³, Haifeng Liu³, Zhenhua Hu^{2

6}, Jie Tian^{1

2

6

9}

Affiliations

¹ Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, China.
² CAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
³ Department of Gastroenterology, the Third Medical Centre, Chinese PLA General Hospital, Beijing, China.
⁴ Department of Control Science and Engineering, Harbin Institute of Technology, Harbin, China.
⁵ Department of Anorectal, the Third medical Centre, Chinese PLA General Hospital, Beijing, China.
⁶ University of Chinese Academy of Sciences, Beijing, China.
⁷ School of Information Sciences and Technology, Northwest University, Xi'an, China.
⁸ Department of Nuclear Medicine, Chinese PLA General Hospital, Beijing, China.
⁹ Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China.

PMID: 31800171
DOI: 10.1002/jbio.201960152

Abstract

Intraoperative Cerenkov luminescence imaging (CLI) can effectively improve the performance of tumor surgery. Nevertheless, the existing approaches are still unsatisfying to the clinical demands of open surgery. This study develops a novel intraoperative in vivo CLI approach to investigate the potential and value of Cerenkov luminescence (CL) image-guided surgery. A system characterized with high sensitivity (19.61 kBq mL^{-1 18} F-FDG) and desirable spatial resolution (88.34 μm) is developed. CL image-guided surgery is performed on colorectal cancer (CRC) models of mice and swine. Tumor surgery is guided by the static CL images, and the resection quality is evaluated quantitatively and contrasted with other imaging modalities exemplified by bioluminescence imaging (BLI). The in vivo results demonstrated the effectiveness of the proposed intraoperative CLI approach for removing primary and metastatic CRC. Safety of performing in vivo CL image-guided surgery is verified as well through radiation measurements of related staffs. Overall, the developed intraoperative in vivo CLI approach can efficiently improve the cancer treatment.

Keywords: Cerenkov luminescence imaging; colorectal cancer; image-guided surgery; in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Colorectal Neoplasms* / diagnostic imaging
Colorectal Neoplasms* / surgery
Fluorodeoxyglucose F18
Luminescence
Luminescent Measurements
Mice
Surgery, Computer-Assisted*
Swine

Substances

Fluorodeoxyglucose F18