Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

Nat Commun. 2019 Dec 20;10(1):5815. doi: 10.1038/s41467-019-13854-3.

Abstract

Locomotor function, mediated by lumbar neural circuitry, is modulated by descending spinal pathways. Spinal cord injury (SCI) interrupts descending projections and denervates lumbar motor neurons (MNs). We previously reported that retrogradely transported neurotrophin-3 (NT-3) to lumbar MNs attenuated SCI-induced lumbar MN dendritic atrophy and enabled functional recovery after a rostral thoracic contusion. Here we functionally dissected the role of descending neural pathways in response to NT-3-mediated recovery after a T9 contusive SCI in mice. We find that residual projections to lumbar MNs are required to produce leg movements after SCI. Next, we show that the spared descending propriospinal pathway, rather than other pathways (including the corticospinal, rubrospinal, serotonergic, and dopaminergic pathways), accounts for NT-3-enhanced recovery. Lastly, we show that NT-3 induced propriospino-MN circuit reorganization after the T9 contusion via promotion of dendritic regrowth rather than prevention of dendritic atrophy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Atrophy / pathology
  • Atrophy / physiopathology
  • Dendrites / pathology
  • Disease Models, Animal
  • Female
  • Humans
  • Locomotion / physiology*
  • Mice
  • Motor Neurons / pathology
  • Motor Neurons / physiology*
  • Nerve Growth Factors / metabolism*
  • Neural Pathways / physiopathology
  • Recovery of Function
  • Spinal Cord / physiopathology*
  • Spinal Cord Injuries / pathology
  • Spinal Cord Injuries / physiopathology*

Substances

  • Nerve Growth Factors
  • neurotropin 3, mouse