The purpose of this study was to explore the expression of Oatp2 transporter in the liver and brain of Alzheimer's disease (AD) mice. The results showed that the protein expression of Oatp2 in the brain significantly decreased in Alzheimer disease mice. On the contrary, protein expression of Oatp2 in liver tissue of AD mice was significantly higher compared with that in normal mice. For mRNA expression of Oatp2, the results showed that, compared with normal mice, it was significantly lower in the brain but significantly higher in liver tissue. Based on the current research, we cannot confirm the relationship between Oatp2 expression and Alzheimer disease. However, it may be a very novel and interesting discovery and may become a new target for the pathogenesis, drug development, and treatment of AD.
Keywords: Alzheimer’s disease; Oatp2; brain; liver.