Cutaneous squamous cell carcinoma in the organ transplant recipient

Kristin Bibee; Andrew Swartz; Shaum Sridharan; Cornelius H L Kurten; Charles B Wessel; Heath Skinner; Dan P Zandberg

doi:10.1016/j.oraloncology.2019.104562

Cutaneous squamous cell carcinoma in the organ transplant recipient

Oral Oncol. 2020 Apr:103:104562. doi: 10.1016/j.oraloncology.2019.104562. Epub 2020 Feb 14.

Authors

Kristin Bibee¹, Andrew Swartz², Shaum Sridharan³, Cornelius H L Kurten⁴, Charles B Wessel⁵, Heath Skinner⁶, Dan P Zandberg⁷

Affiliations

¹ Department of Dermatology, University of Pittsburgh, 3708 Fifth Ave #5, Pittsburgh, PA 15213, USA; Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA 15232, USA. Electronic address: kbibee1@jhmi.edu.
² Department of Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA.
³ Department of Otolaryngology, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213, USA.
⁴ Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA 15232, USA; Department of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Hufelandstrabe 55, 45147 Essen, Germany.
⁵ Health Sciences Library, University of Pittsburgh, 200 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261, USA.
⁶ Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA 15232, USA; Department of Radiation Oncology, University of Pittsburgh, 5115 Centre Ave, Pittsburgh, PA 15232, USA.
⁷ Hillman Cancer Center, University of Pittsburgh Medical Center, 5115 Centre Ave, Pittsburgh, PA 15232, USA; Department of Medicine, University of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA.

Abstract

One in twenty solid organ transplant recipients (SOTRs) will develop a highly morbid or fatal cutaneous carcinoma after transplantation. The majority of these cases develop on the head and neck and may require intervention on the part of dermatology, dermatologic surgery, otolaryngology, transplant medicine, radiation oncology, and medical oncology. In this review, we discuss the problem of cutaneous squamous cell carcinoma (cSCC) in SOTRs as well as the prognostic factors and management strategies to care for this population.

Keywords: Cutaneous head and neck cancer; Immunosuppression; Immunotherapy; Squamous cell carcinoma; Transplant.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Carcinoma, Squamous Cell / etiology*
Carcinoma, Squamous Cell / pathology
Humans
Organ Transplantation / adverse effects*
Organ Transplantation / methods
Prognosis
Skin Neoplasms / etiology*
Skin Neoplasms / pathology
Transplant Recipients / statistics & numerical data*

Abstract

Publication types

MeSH terms

Grants and funding