The Role of MicroRNA-155 in Chlamydia muridarum Infected lungs

Microbes Infect. 2020 Sep;22(8):360-365. doi: 10.1016/j.micinf.2020.02.005. Epub 2020 Feb 19.

Abstract

Our laboratory has investigated the role of an evolutionarily conserved RNA species called microRNAs (miRs) in regulation of anti-chlamydial protective immunity. MiRs including miR-155 expressed in specific immune effector cells are critical for antigen specific protective immunity and IFN-γ production. Using miR-155 deficient mice, and a murine pulmonary model for chlamydial infection, we report here 1) the effect of host miR-155 on bacterial burden, and 2) identify probable immune genes regulated by miR-155.

Keywords: Bacterial burdens; Chlamydia sp; Gene regulation; IFN-γ; Lung; miR-155; microRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Bacterial Load
  • Chlamydia Infections / genetics
  • Chlamydia Infections / immunology
  • Chlamydia Infections / microbiology*
  • Chlamydia muridarum / physiology*
  • Disease Models, Animal
  • Disease Progression
  • Gene Expression Regulation / immunology
  • Interferon-gamma / metabolism
  • Lung / immunology*
  • Lung / microbiology
  • Mice
  • MicroRNAs / genetics
  • MicroRNAs / immunology*

Substances

  • MicroRNAs
  • Mirn155 microRNA, mouse
  • Interferon-gamma