Abstract
Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 108 decrease in bacterial colony-forming units.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / chemistry
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Erythrocytes / drug effects
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Escherichia coli / drug effects*
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Escherichia coli / growth & development
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Escherichia coli Infections / drug therapy
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Hemolysis / drug effects
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Humans
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Light
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Methylene Blue / administration & dosage*
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Methylene Blue / chemistry
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Photochemotherapy
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Photosensitizing Agents / administration & dosage*
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Photosensitizing Agents / chemistry
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Polymyxin B / administration & dosage*
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Polymyxin B / chemistry
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / growth & development
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Skin / drug effects
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Skin / microbiology
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Skin / radiation effects
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Swine
Substances
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Anti-Bacterial Agents
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Photosensitizing Agents
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Polymyxin B
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Methylene Blue