Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy

Rou Zhang; Wenjin Liu; Jian Sun; Yanjie Kong; Ceshi Chen

doi:10.1016/j.phrs.2020.104748

Roles of RNF126 and BCA2 E3 ubiquitin ligases in DNA damage repair signaling and targeted cancer therapy

Pharmacol Res. 2020 May:155:104748. doi: 10.1016/j.phrs.2020.104748. Epub 2020 Mar 6.

Authors

Rou Zhang¹, Wenjin Liu², Jian Sun², Yanjie Kong³, Ceshi Chen⁴

Affiliations

¹ Medical Faculty of Kunming University of Science and Technology, Kunming, Yunnan, 650500, China; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
² Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
³ Institute of Translation Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.
⁴ Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Institute of Translation Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China; KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China; Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China. Electronic address: chenc@mail.kiz.ac.cn.

PMID: 32147403
DOI: 10.1016/j.phrs.2020.104748

Abstract

The dysfunction of E3 ubiquitin ligases is important in the pathogenesis of many human diseases, as they play important roles in multiple cellular processes. In this review, we evaluated the structures, functions and clinical significance of two RING-type E3 ubiquitin ligases from the same subfamily, ring-finger protein 126 (RNF126) and breast cancer associated gene 2 (BCA2). Interestingly, the expression of RNF126 and BCA2 are regulated by multiple signaling pathways, including EGFR, ERK, AKT, and NF-κB. RNF126 and BCA2 appear to be functional mediators for not only DNA damage repair but also cancer development. Due to their significant functions in cell proliferation and DNA damage repair, RNF126 and BCA2 may be two potential diagnostic biomarkers and therapeutic targets for cancers.

Keywords: Apoptosis; DNA damage; Proliferation; Ubiquitination.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA Damage
DNA Repair
Humans
Neoplasms / drug therapy
Neoplasms / enzymology*
Neoplasms / genetics
Signal Transduction
Ubiquitin-Protein Ligases / metabolism*

Substances

RNF115 protein, human
RNF126 protein, human
Ubiquitin-Protein Ligases