Cu2 MoS4 /Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy

Mengyu Chang; Zhiyao Hou; Man Wang; Meifang Wang; Peipei Dang; Jianhua Liu; Mengmeng Shu; Binbin Ding; Abdulaziz A Al Kheraif; Chunxia Li; Jun Lin

doi:10.1002/smll.201907146

Cu₂ MoS₄ /Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy

Small. 2020 Apr;16(14):e1907146. doi: 10.1002/smll.201907146. Epub 2020 Mar 12.

Authors

Mengyu Chang^{1

2}, Zhiyao Hou^{3

4}, Man Wang⁵, Meifang Wang^{1

2}, Peipei Dang^{1

2}, Jianhua Liu⁶, Mengmeng Shu¹, Binbin Ding^{1

2}, Abdulaziz A Al Kheraif⁷, Chunxia Li⁸, Jun Lin^{1

2}

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
² School of Applied Chemistry and Engineering, University of Sciences and Technology of China, Hefei, 230026, P. R. China.
³ Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Guangzhou Medical University, Xinzao Town, Panyu District, Guangzhou, Guangdong, 511436, P. R. China.
⁴ Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, No. 78, Hengzhigang Road, Yuexiu District, Guangzhou, 510095, P. R. China.
⁵ Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua, 321004, P. R. China.
⁶ Department of Radiology, the Second Hospital of Jilin University, Changchun, 130022, P. R. China.
⁷ Dental Health department College of Applied Medical Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.
⁸ Institute of Molecular Sciences and Engineering, Shandong University, Qingdao, 266237, P. R. China.

PMID: 32162784
DOI: 10.1002/smll.201907146

Abstract

Photoimmunotherapy can not only effectively ablate the primary tumor but also trigger strong antitumor immune responses against metastatic tumors by inducing immunogenic cell death. Herein, Cu₂ MoS₄ (CMS)/Au heterostructures are constructed by depositing plasmonic Au nanoparticles onto CMS nanosheets, which exhibit enhanced absorption in near-infrared (NIR) region due to the newly formed mid-gap state across the Fermi level based on the hybridization between Au 5d orbitals and S 3p orbitals, thus resulting in more excellent photothermal therapy and photodynamic therapy (PDT) effect than single CMS upon NIR laser irradiation. The CMS and CMS/Au can also serve as catalase to effectively relieve tumor hypoxia, which can enhance the therapeutic effect of O₂ -dependent PDT. Notably, the NIR laser-irradiated CMS/Au can elicit strong immune responses via promoting dendritic cells maturation, cytokine secretion, and activating antitumor effector T-cell responses for both primary and metastatic tumors eradication. Moreover, CMS/Au exhibits outstanding photoacoustic and computed tomography imaging performance owing to its excellent photothermal conversion and X-ray attenuation ability. Overall, the work provides an imaging-guided and phototherapy-induced immunotherapy based on constructing CMS/Au heterostructures for effectively tumor ablation and cancer metastasis inhibition.

Keywords: CMS/Au heterostructures; PA/CT imaging; hypoxia alleviation; immunotherapy; phototherapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalase / metabolism
Copper* / chemistry
Gold* / chemistry
Humans
Immunotherapy*
Metal Nanoparticles* / chemistry
Molybdenum* / chemistry
Neoplasms* / therapy
Phototherapy*

Substances

Cu(2)MoS(4)
Gold
Copper
Molybdenum
Catalase