Successful Outcome in an Adult Patient with Influenza-associated Hemorrhagic Shock and Encephalopathy Syndrome

Intern Med. 2020 Sep 15;59(18):2321-2326. doi: 10.2169/internalmedicine.4312-19. Epub 2020 Jun 9.

Abstract

A 50-year-old woman presented with coma and hemorrhagic shock. A rapid influenza antigen test revealed influenza A infection; other laboratory examinations ruled out any other suspected infections. She was diagnosed with hemorrhagic shock and encephalopathy syndrome (HSES) induced by influenza A. She was administered methylprednisolone pulse therapy and peramivir. Subsequently, she was discharged without any sequelae. Only a few cases of influenza-induced HSES have been reported, and the clinical outcomes were very poor. We herein report a successfully treated adult case of influenza-induced HSES and review this rare syndrome.

Keywords: HSES; IAE; hemorrhagic shock and encephalopathy syndrome; influenza; influenza-associated encephalopathy.

Publication types

  • Case Reports

MeSH terms

  • Acids, Carbocyclic / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • Blood Coagulation Disorders
  • Brain Diseases
  • Congenital, Hereditary, and Neonatal Diseases and Abnormalities / complications*
  • Congenital, Hereditary, and Neonatal Diseases and Abnormalities / drug therapy
  • Female
  • Guanidines / therapeutic use
  • Humans
  • Influenza A virus
  • Influenza, Human / complications*
  • Influenza, Human / drug therapy
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Shock, Hemorrhagic
  • Syndrome

Substances

  • Acids, Carbocyclic
  • Anti-Inflammatory Agents
  • Antiviral Agents
  • Guanidines
  • peramivir
  • Methylprednisolone

Supplementary concepts

  • Hemorrhagic shock and encephalopathy syndrome