Antiviral mechanisms of candidate chemical medicines and traditional Chinese medicines for SARS-CoV-2 infection

Chang Li; Lin Wang; Linzhu Ren

doi:10.1016/j.virusres.2020.198073

Antiviral mechanisms of candidate chemical medicines and traditional Chinese medicines for SARS-CoV-2 infection

Virus Res. 2020 Sep:286:198073. doi: 10.1016/j.virusres.2020.198073. Epub 2020 Jun 24.

Authors

Chang Li¹, Lin Wang², Linzhu Ren³

Affiliations

¹ Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses, Chinese Academy of Medical Sciences, Military Veterinary Institute, Academy of Military Medical Sciences, Changchun, 130122, China.
² Key Lab for Zoonoses Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
³ Key Lab for Zoonoses Research, Ministry of Education, Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun 130062, China. Electronic address: renlz@jlu.edu.cn.

Abstract

The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic. Up to now, numerous medicines have been applied or approved for the prevention and control of the virus infection. However, the efficiency of each medicine or combination is completely different or still unknown. In this review, we discuss the types, characteristics, antiviral mechanisms, and shortcomings of recommended candidate medicines for SARS-CoV-2 infection, as well as perspectives of the drugs for the disease treatment, which may provide a theoretical basis for drug screening and application.

Keywords: Antiviral; Coronavirus disease 2019 (COVID-19); Medicine; Severe acute respiratory syndrome coronavirus 2 (2019 novel coronavirus, SARS-CoV-2).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine Monophosphate / analogs & derivatives
Adenosine Monophosphate / therapeutic use
Alanine / analogs & derivatives
Alanine / therapeutic use
Amides / therapeutic use
Antiviral Agents / therapeutic use*
Betacoronavirus / drug effects*
Betacoronavirus / immunology
COVID-19
China / epidemiology
Coronavirus Infections / drug therapy*
Coronavirus Infections / epidemiology*
Coronavirus Infections / mortality
Coronavirus Infections / virology
Drug Combinations
Drugs, Chinese Herbal / therapeutic use*
Humans
Hydroxychloroquine / therapeutic use
Indoles / therapeutic use
Interferons / therapeutic use
Lopinavir / therapeutic use
Pandemics*
Pneumonia, Viral / drug therapy*
Pneumonia, Viral / epidemiology*
Pneumonia, Viral / mortality
Pneumonia, Viral / virology
Pyrazines / therapeutic use
Ribavirin / therapeutic use
Ritonavir / therapeutic use
SARS-CoV-2
Survival Analysis
Teicoplanin / therapeutic use

Substances

Amides
Antiviral Agents
Drug Combinations
Drugs, Chinese Herbal
Indoles
Pyrazines
lopinavir-ritonavir drug combination
Lopinavir
remdesivir
Adenosine Monophosphate
Ribavirin
Hydroxychloroquine
Teicoplanin
Interferons
umifenovir
favipiravir
Ritonavir
Alanine