Multiple Somatic Mutations for Clonal Hematopoiesis Are Associated With Increased Mortality in Patients With Chronic Heart Failure

Circ Genom Precis Med. 2020 Aug;13(4):e003003. doi: 10.1161/CIRCGEN.120.003003. Epub 2020 Jun 29.

Sebastian Cremer^{1

2}, Klara Kirschbaum³, Alexander Berkowitsch³, David John¹, Katharina Kiefer⁴, Lena Dorsheimer⁴, Julian Wagner¹, Tina Rasper¹, Khalil Abou-El-Ardat⁴, Birgit Assmus^{3

2

5}, Hubert Serve⁴, Michael Rieger⁴, Stefanie Dimmeler¹, Andreas M Zeiher^{3

2}

¹ Institute for Cardiovascular Regeneration (S.C., D.J., J.W., T.R., S.D.), Goethe University, Frankfurt.
² German Center for Cardiovascular Research, Berlin (partner site Frankfurt Rhine-Main) (S.C., B.A., S.D., A.M.Z.).
³ Departments of Medicine and Cardiology (S.C., K. Kirschbaum, A.B., B.A., A.M.Z.), Goethe University, Frankfurt.
⁴ Department of Medicine, Hematology/Oncology, Goethe University Hospital (K. Kiefer, L.D., K.A.-E.A., H.S., M.R.), Goethe University, Frankfurt.
⁵ Department of Medicine, Cardiology, Gießen University Hospital, Frankfurt (B.A.).

No abstract available

Keywords: bone marrow; heart failure; immune system; inflammation.

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