The Lysosome at the Intersection of Cellular Growth and Destruction

Dev Cell. 2020 Jul 20;54(2):226-238. doi: 10.1016/j.devcel.2020.06.010. Epub 2020 Jun 30.

Abstract

The lysosome is an essential catabolic organelle that consumes cellular biomass to regenerate basic building blocks that can fuel anabolic reactions. This simple view has evolved more recently to integrate novel functions of the lysosome as a key signaling center, which can steer the metabolic trajectory of cells in response to changes in nutrients, growth factors, and stress. Master protein kinases and transcription factors mediate the growth-promoting and catabolic activities of the lysosome and undergo a complex interplay that enables cellular adaptation to ever-changing metabolic conditions. Understanding how this coordination occurs will shed light on the fundamental logic of how the lysosome functions to control growth in the context of development, tissue homeostasis, and cancer.

Keywords: TFEB; anabolism; autophagy; catabolism; lysosome; mTORC1; nutrient sensing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy / physiology*
  • Cell Cycle / physiology*
  • Cell Proliferation / physiology*
  • Homeostasis / physiology
  • Humans
  • Mechanistic Target of Rapamycin Complex 1 / metabolism
  • Signal Transduction / physiology*

Substances

  • Mechanistic Target of Rapamycin Complex 1