COVID-19: Progress in diagnostics, therapy and vaccination

Theranostics. 2020 Jun 19;10(17):7821-7835. doi: 10.7150/thno.47987. eCollection 2020.

Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden emergence and rapid spread of SARS-CoV-2 is endangering global health and the economy, the development of strategies to contain the virus's spread are urgently needed. At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. Several drugs have demonstrated in vitro activity against SARS-CoV-2 or potential clinical benefits. In addition, institutions and companies worldwide are working tirelessly to develop treatments and vaccines against COVID-19. However, no drug or vaccine has yet been specifically approved for COVID-19. Given the urgency of the outbreak, we focus here on recent advances in the diagnostics, treatment, and vaccine development for SARS-CoV-2 infection, helping to guide strategies to address the current COVID-19 pandemic.

Keywords: COVID-19; SARS-CoV-2; antiviral therapy; diagnostics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / isolation & purification
  • Antiviral Agents / therapeutic use
  • Betacoronavirus* / genetics
  • Betacoronavirus* / immunology
  • Betacoronavirus* / isolation & purification
  • COVID-19
  • COVID-19 Drug Treatment
  • COVID-19 Serotherapy
  • COVID-19 Testing
  • COVID-19 Vaccines
  • Clinical Laboratory Techniques* / trends
  • Coronavirus Infections* / diagnosis
  • Coronavirus Infections* / drug therapy
  • Coronavirus Infections* / prevention & control
  • Coronavirus Infections* / therapy
  • Drug Development / trends
  • Humans
  • Immunization, Passive / trends
  • Pandemics* / prevention & control
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / prevention & control
  • Pneumonia, Viral* / therapy
  • SARS-CoV-2
  • Theranostic Nanomedicine / trends
  • Viral Vaccines* / isolation & purification
  • Viral Vaccines* / pharmacology

Substances

  • Antiviral Agents
  • COVID-19 Vaccines
  • Viral Vaccines