Molecular mechanisms of action of resveratrol in modulation of diabetic and non-diabetic cardiomyopathy

Pharmacol Res. 2020 Nov:161:105112. doi: 10.1016/j.phrs.2020.105112. Epub 2020 Aug 3.

Abstract

Cardiomyopathy is among the major clinical manifestations of heart diseases that triggers malfunctioning of the cardiovascular system. Some of the major causal factors of cardiomyopathy includes myocardial ischemia, drug-toxicity, genetic aberrations, abnormal depositions of essential elements, and redox imbalance. Diabetes, being the major comorbid of cardiovascular diseases and vice versa, further contributes to the progression of cardiomyopathy. The molecular mechanisms of action suggest that oxidative stress is among the primary factors that triggers cascading impact on cardiomyopathy. Resveratrol, a phenolic antioxidant, has the potential to quench the excessive free radicals. It is a potent antioxidant supplement that may as well be a therapeutic molecule. The review focuses on the various molecular mechanisms of action that resveratrol potentiates in reversing or attenuating the progress of diabetic and non-diabetic cardiomyopathy triggered by wide range of factors. Additionally, resveratrol also tends to preserve the healthy heart from potential damage that may be triggered by oxidative stress.

Keywords: Cardiomyopathy; Diabetes; Ischemia reperfusion injury; Resveratrol; SIRT1.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Cardiomyopathies / drug therapy*
  • Cardiomyopathies / metabolism
  • Cardiomyopathies / pathology
  • Cardiomyopathies / physiopathology
  • Diabetic Cardiomyopathies / drug therapy*
  • Diabetic Cardiomyopathies / metabolism
  • Diabetic Cardiomyopathies / pathology
  • Diabetic Cardiomyopathies / physiopathology
  • Disease Models, Animal
  • Humans
  • Myocytes, Cardiac / drug effects*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / pathology
  • Oxidative Stress / drug effects*
  • Resveratrol / pharmacology*
  • Signal Transduction

Substances

  • Antioxidants
  • Resveratrol