Dual-specificity phosphatases in mental and neurological disorders

Prog Neurobiol. 2021 Mar:198:101906. doi: 10.1016/j.pneurobio.2020.101906. Epub 2020 Sep 6.

Abstract

The dual-specificity phosphatase (DUSP) family includes a heterogeneous group of protein phosphatases that dephosphorylate both phospho-tyrosine and phospho-serine/phospho-threonine residues within a single substrate. These protein phosphatases have many substrates and modulate diverse neural functions, such as neurogenesis, differentiation, and apoptosis. DUSP genes have furthermore been associated with mental disorders such as depression and neurological disorders such as Alzheimer's disease. Herein, we review the current literature on the DUSP family of genes concerning mental and neurological disorders. This review i) outlines the structure and general functions of DUSP genes, and ii) overviews the literature on DUSP genes concerning mental and neurological disorders, including model systems, while furthermore providing perspectives for future research.

Keywords: DUSP; Mental health; Neurological diseases; Phosphatase; Psychiatric disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dual-Specificity Phosphatases
  • Humans
  • Nervous System Diseases* / genetics
  • Neurogenesis
  • Phosphoprotein Phosphatases

Substances

  • Phosphoprotein Phosphatases
  • Dual-Specificity Phosphatases