The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

Pasquale L Fedele; Yang Liao; Jia-Nan Gong; Yuan Yao; Mark F van Delft; Michael S Y Low; Lin Tai; Marco J Herold; Jacob T Jackson; Charis E Teh; Tania Tan; Lorraine A O'Reilly; Julie Tellier; George Grigoriadis; David C S Huang; Wei Shi; Stephen L Nutt; Simon N Willis

doi:10.1038/s41375-020-01078-0

The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival

Leukemia. 2021 Jul;35(7):2114-2118. doi: 10.1038/s41375-020-01078-0. Epub 2020 Nov 4.

Authors

Pasquale L Fedele^{1

2

3

4}, Yang Liao^{1

2

5

6}, Jia-Nan Gong^{1

2}, Yuan Yao^{1

2

7}, Mark F van Delft^{1

2}, Michael S Y Low^{3

4}, Lin Tai¹, Marco J Herold^{1

2}, Jacob T Jackson^{1

2}, Charis E Teh^{1

2}, Tania Tan¹, Lorraine A O'Reilly^{1

2}, Julie Tellier^{1

2}, George Grigoriadis^{3

4}, David C S Huang^{1

2}, Wei Shi^{1

5

6

8}, Stephen L Nutt^#^{9

10}, Simon N Willis^#^{11

12}

Affiliations

¹ The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia.
² Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia.
³ Haematology Department, Monash Health, Clayton, VIC, 3168, Australia.
⁴ School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
⁵ Olivia Newton-John Cancer Research Institute, Heidelberg, VIC, 3084, Australia.
⁶ School of Cancer Medicine, La Trobe University, Heidelberg, VIC, 3084, Australia.
⁷ School of Medicine, Tsinghua University, Beijing, China.
⁸ School of Computing and Information Systems, The University of Melbourne, Parkville, VIC, 3010, Australia.
⁹ The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. nutt@wehi.edu.au.
¹⁰ Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia. nutt@wehi.edu.au.
¹¹ The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. willis@wehi.edu.au.
¹² Department of Medical Biology, The University of Melbourne, Parkville, VIC, 3010, Australia. willis@wehi.edu.au.

^# Contributed equally.

PMID: 33149265
DOI: 10.1038/s41375-020-01078-0

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Apoptosis / genetics*
Apoptosis Regulatory Proteins / genetics*
Bcl-2-Like Protein 11 / genetics*
Cell Line, Tumor
Humans
Interferon Regulatory Factors / genetics*
Multiple Myeloma / genetics*
Multiple Myeloma / mortality
Survival Rate

Substances

Adaptor Proteins, Signal Transducing
Apoptosis Regulatory Proteins
BMF protein, human
Bcl-2-Like Protein 11
Interferon Regulatory Factors
interferon regulatory factor-4

Associated data

figshare/10.6084/m9.figshare.9201770.v2

Grants and funding

1155342/Department of Health | National Health and Medical Research Council (NHMRC)