On the Improper Use of the Term High-Density Neutrophils

Marco A Cassatella; Patrizia Scapini

doi:10.1016/j.it.2020.10.008

On the Improper Use of the Term High-Density Neutrophils

Trends Immunol. 2020 Dec;41(12):1059-1061. doi: 10.1016/j.it.2020.10.008. Epub 2020 Nov 4.

Authors

Marco A Cassatella¹, Patrizia Scapini²

Affiliations

¹ Department of Medicine, Section of General Pathology, Strada Le Grazie 4, 37138 Verona, University of Verona, Italy. Electronic address: marco.cassatella@univr.it.
² Department of Medicine, Section of General Pathology, Strada Le Grazie 4, 37138 Verona, University of Verona, Italy.

PMID: 33160842
DOI: 10.1016/j.it.2020.10.008

Abstract

Recent studies have revealed that neutrophils exhibit an unsuspected heterogeneity. In this context, the term high-density neutrophils (HDNs) has recently gained ground to define nothing more than neutrophils displaying an unaltered normal density. Therefore, as discussed here, we argue that the HDNs term must be avoided, as it is confounding and scientifically inappropriate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Count
Humans
Neutrophils* / cytology
Terminology as Topic*