Evaluation of a Nutraceutical Product with Probiotics, Vitamin D, Plus Banaba Leaf Extracts (Lagerstroemia speciosa) in Glycemic Control

Endocr Metab Immune Disord Drug Targets. 2021;21(7):1356-1365. doi: 10.2174/1871530320666201109115415.

Abstract

Background: Dysbiosis is related to changes in the composition and behaviour of intestinal microbiota, which may contribute to an age-related decline in metabolic and immune system functioning (immune-senescence).

Objective: The microbiota-targeted dietary and probiotic interventions have been shown to favorably affect the host health by an enhancement of antioxidant activity, improving immune homeostasis, suppression of chronic inflammation, regulation of metabolism and prevention of insulin resistance.

Results: In our study, the use of specific probiotics strains improved the serum concentration of glycemic markers, thereby promoting better overall health.

Conclusion: Probiotics may help correct defects in the gut microbial environment improving metabolic parameters, such as blood sugar levels, glycosylated hemoglobin and a decrease in body weight.

Keywords: Banaba leaf extracts; Lagerstroemia speciosa.; Probiotics; Vitamin D; cholecalciferol; translational medicine.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Albania
  • Biomarkers / blood
  • Blood Glucose / drug effects*
  • Blood Glucose / metabolism
  • Cholecalciferol / adverse effects
  • Cholecalciferol / therapeutic use*
  • Double-Blind Method
  • Dysbiosis
  • Female
  • Gastrointestinal Microbiome*
  • Glycated Hemoglobin / metabolism
  • Glycemic Control*
  • Humans
  • Intestines / microbiology*
  • Italy
  • Lagerstroemia* / chemistry
  • Male
  • Middle Aged
  • Plant Extracts / adverse effects
  • Plant Extracts / therapeutic use*
  • Plant Leaves
  • Probiotics / adverse effects
  • Probiotics / therapeutic use*
  • Time Factors
  • Treatment Outcome
  • Weight Loss / drug effects

Substances

  • Biomarkers
  • Blood Glucose
  • Glycated Hemoglobin A
  • Plant Extracts
  • hemoglobin A1c protein, human
  • Cholecalciferol