Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome

Minoru Takemoto; Yoshitaka Kubota; Toshibumi Taniguchi; Sei-Ichiro Motegi; Akira Taniguchi; Hironori Nakagami; Yoshiro Maezawa; Masaya Koshizaka; Hisaya Kato; Kazuhisa Tsukamoto; Seijiro Mori; Masafumi Kuzuya; Koutaro Yokote

doi:10.1111/ggi.14083

Management guideline for Werner syndrome 2020. 3. Diabetes associated with Werner syndrome

Geriatr Gerontol Int. 2021 Feb;21(2):142-145. doi: 10.1111/ggi.14083. Epub 2020 Nov 9.

Authors

Affiliations

¹ Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare, Chiba, Japan.
² Department of Plastic, Reconstructive, and Aesthetic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
³ Department of Infectious Diseases, Chiba University Hospital, Chiba, Japan.
⁴ Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan.
⁵ Department of Orthopaedic Surgery, Nara Medical University, Nara, Japan.
⁶ Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
⁷ Department of Endocrinology, Hematology and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
⁸ Department of Internal Medicine, School of Medicine, Teikyo University, Tokyo, Japan.
⁹ Center for the Promotion of Clinical Investigation, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
¹⁰ Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Institutes of Innovation for Future Society, Nagoya University, Nagoya, Japan.

PMID: 33169495
DOI: 10.1111/ggi.14083

Abstract

Aims: To evaluate the characteristics of diabetes associated with Werner syndrome.

Methods: A literature search was done with search term "Werner syndrome" and "Diabetes".

Results and conclusions: Prevalence of diabetes is extremely high in Werner syndrome. Diabetes associated with Werner syndrome is classified as "accompanied with other diseases and conditions and the one occurring mainly in association with other genetic syndromes." This type of diabetes is marked by accumulated visceral fat and high insulin resistance, despite low body mass index. Thiazolidine derivatives and metformin are effective for glycemic control. New antidiabetic drugs, such as dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists, could be potentially beneficial for patients with Werner syndrome. Furthermore, the establishment of diet therapy as well as exercise therapy is warranted. Geriatr Gerontol Int 2021; 21: 142-145.

Keywords: clinical medicine; geriatric medicine; others.

MeSH terms

Diabetes Mellitus, Type 2*
Dipeptidyl-Peptidase IV Inhibitors*
Humans
Hypoglycemic Agents / therapeutic use
Metformin* / therapeutic use
Werner Syndrome*

Substances

Dipeptidyl-Peptidase IV Inhibitors
Hypoglycemic Agents
Metformin