Tissue-specific adrenergic regulation of the L-type Ca2+ channel CaV1.2

Sci Signal. 2020 Dec 22;13(663):eabc6438. doi: 10.1126/scisignal.abc6438.

Abstract

Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Cav1.2 and, consequently, cardiomyocyte contractility. Emerging evidence shows that Cav1.2 is regulated by different mechanisms in cardiomyocytes compared to neurons and vascular smooth muscle cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adrenergic Agents / metabolism*
  • Animals
  • Calcium Channels, L-Type / metabolism*
  • Calcium Signaling*
  • Cyclic AMP / metabolism*
  • Humans
  • Muscle, Smooth, Vascular / metabolism*
  • Myocytes, Cardiac / metabolism*
  • Myocytes, Smooth Muscle / metabolism*

Substances

  • Adrenergic Agents
  • CACNA1C protein, human
  • Calcium Channels, L-Type
  • Cyclic AMP