Smart and Biostable Polyurethanes for Long-Term Implants

Seungil Kim; Song Liu

doi:10.1021/acsbiomaterials.8b00301

Smart and Biostable Polyurethanes for Long-Term Implants

ACS Biomater Sci Eng. 2018 May 14;4(5):1479-1490. doi: 10.1021/acsbiomaterials.8b00301. Epub 2018 Mar 23.

Authors

Seungil Kim¹, Song Liu^{1

2

3}

Affiliations

¹ Biomedical Engineering, Faculty of Engineering, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
² Department of Biosystems Engineering, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
³ Department of Medical Microbiology, Rady Faculty of Health Science, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.

PMID: 33445305
DOI: 10.1021/acsbiomaterials.8b00301

Abstract

This article reviews stimuli-responsive and biostable polyurethanes (PUs) and discusses biomedical applications of smart PUs with a particular focus on long-term implantable PU biomaterials such as PU generated artificial blood vessels, artificial intervertebral discs (IVDs), and intravaginal rings (IVRs). Recently, smart PUs have been actively researched to enhance bioactivity, biocompatibility, and reduce drug side effects. Although biodegradability is important in regenerative medicine, biostability of PU plays a key role for long-term implantable biomaterials. This article reviews recent publications of research and inventions of stimuli-responsive and biostable PUs. Applications of smart PUs in long-term implantable biomaterials are discussed and linked to the future outlook of smart biostable PU biomaterials.

Keywords: biostable polyurethane; long-term implants; polyurethane biomaterials; smart polyurethane.