Reduced CXCL4/PF4 expression as a driver of increased human hematopoietic stem and progenitor cell proliferation in polycythemia vera

Blood Cancer J. 2021 Feb 11;11(2):31. doi: 10.1038/s41408-021-00423-5.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Cell Proliferation* / drug effects
  • Down-Regulation* / drug effects
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Hydroxyurea / therapeutic use
  • Platelet Factor 4 / genetics*
  • Polycythemia Vera / drug therapy
  • Polycythemia Vera / genetics*
  • Transcriptome / drug effects

Substances

  • Antineoplastic Agents
  • PF4 protein, human
  • Platelet Factor 4
  • Hydroxyurea