Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis

Signal Transduct Target Ther. 2021 Feb 28;6(1):92. doi: 10.1038/s41392-021-00483-w.

Authors

Chuang Yuan¹, Ming Wu², Qicai Xiao¹, Wang Zhao¹, Hongli Li¹, Yanjun Zhong¹, Minyi Zhao¹, Cheng Li¹, Yang Li³, Xinyu Yang⁴

Affiliations

¹ Department of Hematology, Xiangya Hospital, Central South University, Changsha, PR China.
² Department of Critical Care Medicine, The Second People's Hospital of Shenzhen & First Affiliated Hospital of Shenzhen University, Shenzhen, PR China.
³ Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, P R China.
⁴ Department of Hematology, Xiangya Hospital, Central South University, Changsha, PR China. yangxinyu@csu.edu.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Berberine Alkaloids / pharmacology*
Blood Coagulation / drug effects*
Blood Coagulation / genetics
Caspases / genetics
Caspases / metabolism*
Caspases, Initiator / genetics
Caspases, Initiator / metabolism*
Escherichia coli / metabolism*
Humans
Mice
Mice, Knockout
Scavenger Receptors, Class A / genetics
Scavenger Receptors, Class A / metabolism*
Sepsis / genetics
Sepsis / metabolism*
Sepsis / microbiology
THP-1 Cells

Substances

Berberine Alkaloids
MSR1 protein, human
Msr1 protein, mouse
Scavenger Receptors, Class A
Casp4 protein, mouse
Caspases
Caspases, Initiator
caspase 11, human