Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-1c/FASN axis

Signal Transduct Target Ther. 2021 Mar 1;6(1):98. doi: 10.1038/s41392-021-00493-8.

Jun Deng^#¹, Mei Peng^#^{2

3}, Sichun Zhou¹, Di Xiao¹, Xin Hu¹, Simeng Xu¹, Jingtao Wu¹, Xiaoping Yang⁴

¹ Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy School of Medicine, Hunan Normal University, Changsha 410013, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.
² Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy School of Medicine, Hunan Normal University, Changsha 410013, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China. Meipeng@csu.edu.cn.
³ Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China. Meipeng@csu.edu.cn.
⁴ Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, Department of Pharmacy School of Medicine, Hunan Normal University, Changsha 410013, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China. Xiaoping.Yang@hunnu.edu.cn.

^# Contributed equally.

No abstract available

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