Enrichment of CCR6+ CD8+ T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19

Eur J Immunol. 2021 Jun;51(6):1535-1538. doi: 10.1002/eji.202049046. Epub 2021 May 11.

Abstract

Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. ​.

Keywords: CCL20; CCR6; COVID-19; T cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / pathology
  • COVID-19 / immunology*
  • COVID-19 / pathology
  • COVID-19 / therapy
  • Chemokine CCL20 / immunology*
  • Female
  • Humans
  • Lung / immunology*
  • Lung / pathology
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Receptors, CCR6 / immunology*
  • Respiration, Artificial*
  • SARS-CoV-2 / immunology*

Substances

  • CCL20 protein, human
  • CCR6 protein, human
  • Chemokine CCL20
  • Receptors, CCR6