Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population

Pharmacogenomics. 2021 Apr;22(6):323-334. doi: 10.2217/pgs-2020-0140. Epub 2021 Apr 1.

Abstract

Aim: This study investigated major allelic variants of CYP2D6, CYP3A4 and CYP3A5 in Egyptians, an Arabic population for which there is little information regarding these important pharmacogenes. Patients & methods:CYP2D6*2, *4, *5, *10, *41 and gene copy number variation, as well as CYP3A4*22 and CYP3A5*3 were determined with commercially available TaqMan assays in 145 healthy study participants. Results: The CYP2D6 alleles identified suggest that the prevalence of poor metabolizers is low as none were found among the 145 subjects investigated. The frequency for CYP3A5 nonexpressers was 74.5% and the CYP3A4*22 allele frequency was low at 2.0%. Conclusion: These preliminary findings indicate that pharmacogene variation in Egyptians is different from those of other Middle Eastern/Arabic populations and warrants further investigation.

Keywords: CYP2D6; CYP3A4; CYP3A5; genotype; phenotype Egyptian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Arabs
  • Child
  • Cytochrome P-450 CYP2D6 / genetics*
  • Cytochrome P-450 CYP3A / genetics*
  • Egypt / epidemiology
  • Female
  • Gene Dosage
  • Gene Frequency
  • Genetic Variation
  • Genotype
  • Healthy Volunteers
  • Humans
  • Male
  • Prevalence

Substances

  • CYP3A5 protein, human
  • Cytochrome P-450 CYP2D6
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human