Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart

Circulation. 2021 May 25;143(21):2123-2125. doi: 10.1161/CIRCULATIONAHA.120.052799. Epub 2021 May 24.

¹ Departments of Cardiology (M. Isomi, T. Sadahiro, R.F., Y.Y., Y.A., Y.M., T.A., M. Ieda), University of Tsukuba, Ibaraki, Japan.
² Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.Y., K.F.).
³ Faculty of Medicine, and Division of Regenerative Medicine, Transborder Medical Research Center (R.F.), University of Tsukuba, Ibaraki, Japan.
⁴ Respiratory Medicine (T.A.), University of Tsukuba, Ibaraki, Japan.
⁵ ID Pharma Co, Ltd, R&D Center, Techno Park Oho, Tsukuba, Ibaraki, Japan (T. Shu).
⁶ Division of Genetic Therapeutics, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan (H.M.).

No abstract available

Keywords: fibroblasts; mice; myocytes, cardiac; regeneration.

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