Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure

Circ Res. 2021 Jul 23;129(3):400-413. doi: 10.1161/CIRCRESAHA.120.318149. Epub 2021 Jun 3.

Authors

Jin-Ling Huo¹, Lemin Jiao¹, Qi An¹, Xiuying Chen¹, Yuruo Qi¹, Bingfei Wei¹, Yichao Zheng¹, Xiaojing Shi¹, Erhe Gao², Hong-Min Liu¹, Dong Chen^#³, Cong Wang^#¹, Wen Zhao^#¹

Affiliations

¹ State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China; School of Pharmaceutical Sciences, Zhengzhou University (J.-L.H., L.J., Q.A., X.C., Y.Q., B.W., Y.Z., X.S., H.-M.L., C.W., W.Z.).
² Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA (E.G.).
³ Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, China (D.C.).

^# Contributed equally.

PMID: 34078090
DOI: 10.1161/CIRCRESAHA.120.318149

Abstract

[Figure: see text].

Keywords: fibrosis; heart failure; histone; hypertrophy; myofibroblast.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Aortic Valve Stenosis / complications
Cells, Cultured
Heart Failure / etiology
Heart Failure / metabolism*
Heart Failure / physiopathology
Histone Demethylases / genetics
Histone Demethylases / metabolism*
Humans
MAP Kinase Signaling System
Mice
Mice, Inbred C57BL
Myocytes, Cardiac / metabolism
Myofibroblasts / metabolism*
Myofibroblasts / pathology
Rats
Rats, Sprague-Dawley
Smad Proteins / metabolism
Transforming Growth Factor beta / metabolism
p38 Mitogen-Activated Protein Kinases / metabolism

Substances

Smad Proteins
Transforming Growth Factor beta
Histone Demethylases
KDM1a protein, mouse
p38 Mitogen-Activated Protein Kinases