Zoonotic and Reverse Zoonotic Transmissibility of SARS-CoV-2

Virus Res. 2021 Sep:302:198473. doi: 10.1016/j.virusres.2021.198473. Epub 2021 Jun 9.

Abstract

The Coronavirus Disease 2019 (COVID-19) is the first known pandemic caused by a coronavirus. Its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), appears to be capable of infecting different mammalian species. Recent detections of this virus in pet, zoo, wild, and farm animals have compelled inquiry regarding the zoonotic (animal-to-human) and reverse zoonotic (human-to-animal) transmissibility of SARS-CoV-2 with the potential of COVID-19 pandemic evolving into a panzootic. It is important to monitor the global spread of disease and to assess the significance of genomic changes to support prevention and control efforts during a pandemic. An understanding of the SARS-CoV-2 epidemiology provides opportunities to prevent the risk of repeated re-infection of humans and requires a robust One Health-based investigation. This review paper describes the known properties and the existing gaps in scientific knowledge about the zoonotic and reverse zoonotic transmissibility of the novel virus SARS-CoV-2 and the COVID-19 disease it causes.

Keywords: COVID-19; Coronavirus; Intermediate host; SARS-CoV-2; Transmission; Zoonoses.

Publication types

  • Review

MeSH terms

  • Animals
  • COVID-19 / epidemiology
  • COVID-19 / prevention & control
  • COVID-19 / transmission*
  • COVID-19 / virology
  • Humans
  • One Health
  • Pandemics*
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / physiology*
  • Zoonoses