DRD4 (Dopamine D4 Receptor) Mitigate Abdominal Aortic Aneurysm via Decreasing P38 MAPK (mitogen-activated protein kinase)/NOX4 (NADPH Oxidase 4) Axis-Associated Oxidative Stress

Hypertension. 2021 Aug;78(2):294-307. doi: 10.1161/HYPERTENSIONAHA.120.16738. Epub 2021 Jun 28.

Abstract

[Figure: see text].

Keywords: NADPH oxidase 4; aortic aneurysm, abdominal; dopamine D4 receptor; oxidative stress; reactive oxygen species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta, Abdominal / metabolism*
  • Aortic Aneurysm, Abdominal / genetics
  • Aortic Aneurysm, Abdominal / metabolism*
  • Mice
  • Mice, Knockout
  • Muscle, Smooth, Vascular / metabolism
  • NADPH Oxidase 4 / metabolism*
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism
  • Receptors, Dopamine D4 / genetics
  • Receptors, Dopamine D4 / metabolism*
  • Signal Transduction / physiology
  • p38 Mitogen-Activated Protein Kinases / metabolism*

Substances

  • Drd4 protein, mouse
  • Reactive Oxygen Species
  • Receptors, Dopamine D4
  • NADPH Oxidase 4
  • p38 Mitogen-Activated Protein Kinases