Comparison of characteristics and biocompatibility of green synthesized iron oxide nanoparticles with chemical synthesized nanoparticles

Mohammed Junaid Hussain Dowlath; Shazia Anjum Musthafa; S B Mohamed Khalith; Sunita Varjani; Sathish Kumar Karuppannan; Ganesh Munuswamy Ramanujam; Aarrthy M Arunachalam; Kantha Deivi Arunachalam; Murugesan Chandrasekaran; Soon Woong Chang; Woo Jin Chung; Balasubramani Ravindran

doi:10.1016/j.envres.2021.111585

Comparison of characteristics and biocompatibility of green synthesized iron oxide nanoparticles with chemical synthesized nanoparticles

Environ Res. 2021 Oct:201:111585. doi: 10.1016/j.envres.2021.111585. Epub 2021 Jun 25.

Affiliations

¹ Center for Environmental Nuclear Research, Directorate of Research and Virtual Education, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
² Interdisciplinary Institute of Indian System of Medicine, Directorate of Research and Virtual Education, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India; Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
³ Gujarat Pollution Control Board, Gandhinagar, 382 010, Gujarat, India.
⁴ Interdisciplinary Institute of Indian System of Medicine, Directorate of Research and Virtual Education, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India; Department of Chemistry, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.
⁵ Department of Emergency Medicine, Howard University, Kaplan Medical Center, Washington, DC, USA.
⁶ Center for Environmental Nuclear Research, Directorate of Research and Virtual Education, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India. Electronic address: dean.cenr@srmist.edu.in.
⁷ Department of Food Science and Biotechnology, Sejong University, Gwangjin-gu, Seoul, 05006, Republic of Korea.
⁸ Department of Environmental Energy and Engineering, Kyonggi University, Youngtong-Gu, Suwon, Gyeonggi-Do, 16227, Republic of Korea.
⁹ Center for Environmental Nuclear Research, Directorate of Research and Virtual Education, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India; Department of Environmental Energy and Engineering, Kyonggi University, Youngtong-Gu, Suwon, Gyeonggi-Do, 16227, Republic of Korea. Electronic address: kalamravi@gmail.com.

PMID: 34181925
DOI: 10.1016/j.envres.2021.111585

Abstract

Iron oxide nanoparticles synthesis is an expanding area of research due of their magnetic properties and possible applications in several novel technologies. FeONPs are indispensable in the biomedical field for diagnosis, treatments and drug delivery and in bioremediation applications. The synthesis route of nanoparticles is a major concern because biological methods are eco-friendly, and chemical methods are considered toxic. The objective of this study is to synthesize FeONPs by two different methods and to compare their properties and efficiency in applications. FeONPs were synthesized and characterized by microscopic and various spectroscopic techniques. The synthesized FeONPs were screened for their cytotoxic activity on PBMCs using MTT assay and found to exhibit good biocompatibility. Moreover, the GS FeONPs exhibited potential antibacterial activities and meanwhile showed less toxicity in brine shrimp lethality assay. Hence, these nanoparticles are biocompatible, environmentally safe and can be utilized in many medical applications.

Keywords: Brine shrimp assay; Cardiospermum halicacabum; Cytotoxicity; Magnetic materials; Peripheral blood mononuclear cells; ROS scavenging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials
Green Chemistry Technology*
Magnetic Iron Oxide Nanoparticles*
Metal Nanoparticles

Substances

Biocompatible Materials