Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue

G N Zyuz'kov; V V Zhdanov; L A Miroshnichenko; T Yu Polyakova; E V Simanina; L A Stavrova; M G Danilets; V I Agafonov; A V Chaikovskii

doi:10.1007/s10517-021-05222-3

Role of JNK and p53 in Implementation of Functions of Various Types of Regeneration-Competent Cells of the Nervous Tissue

Bull Exp Biol Med. 2021 Jul;171(3):333-337. doi: 10.1007/s10517-021-05222-3. Epub 2021 Jul 23.

Authors

G N Zyuz'kov¹, V V Zhdanov², L A Miroshnichenko², T Yu Polyakova², E V Simanina², L A Stavrova², M G Danilets², V I Agafonov², A V Chaikovskii²

Affiliations

¹ E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. zgn@pharmso.ru.
² E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

PMID: 34297290
DOI: 10.1007/s10517-021-05222-3

Abstract

We studied the participation of JNK and p53 in the realization of the growth potential of different types of progenitors of the subventricular zone of mouse brain and secretion of neurotrophins by glial cells. The stimulating role of these signaling molecules in mitotic activity and specialization of multipotent neural stem cells was shown. It was found that JNK and p53 do not participate in the regulation of committed neuronal progenitor cells (clonogenic PSA-NCAM⁺ cells). A dependence of neurotrophic growth factors in individual populations of neuroglia on activity of these protein kinase and transcription factor was revealed. The role of JNK and p53 in astrocytes consists in stimulation of their secretion, and in microglial cells, on the contrary, in its inhibition. The secretory neurotrophic function of oligodendrogliocytes is not associated with JNK and p53 activity.

Keywords: intracellular signaling molecules; neural stem cells; neurodegenerative diseases; neuroglia; targeted therapy.

MeSH terms

Animals
Astrocytes / cytology
Astrocytes / drug effects
Astrocytes / metabolism*
Benzothiazoles / pharmacology
CD56 Antigen / genetics
CD56 Antigen / metabolism
Culture Media, Conditioned / pharmacology
Gene Expression Regulation
Lateral Ventricles / cytology
Lateral Ventricles / drug effects
Lateral Ventricles / metabolism
MAP Kinase Kinase 4 / genetics*
MAP Kinase Kinase 4 / metabolism
Mice
Mice, Inbred C57BL
Multipotent Stem Cells / cytology
Multipotent Stem Cells / drug effects
Multipotent Stem Cells / metabolism*
Nerve Growth Factors / biosynthesis
Nerve Growth Factors / genetics
Neural Cell Adhesion Molecules / genetics
Neural Cell Adhesion Molecules / metabolism
Neural Stem Cells / cytology
Neural Stem Cells / drug effects
Neural Stem Cells / metabolism*
Neuroglia / cytology
Neuroglia / drug effects
Neuroglia / metabolism*
Signal Transduction
Toluene / analogs & derivatives
Toluene / pharmacology
Tumor Suppressor Protein p53 / genetics*
Tumor Suppressor Protein p53 / metabolism

Substances

Benzothiazoles
CD56 Antigen
Culture Media, Conditioned
Nerve Growth Factors
Neural Cell Adhesion Molecules
Tumor Suppressor Protein p53
Toluene
pifithrin
MAP Kinase Kinase 4