Minireview: What is Known about SUMOylation Among NR4A Family Members?

Fatéma Dodat; Sylvie Mader; Daniel Lévesque

doi:10.1016/j.jmb.2021.167212

Minireview: What is Known about SUMOylation Among NR4A Family Members?

J Mol Biol. 2021 Oct 15;433(21):167212. doi: 10.1016/j.jmb.2021.167212. Epub 2021 Aug 23.

Authors

Fatéma Dodat¹, Sylvie Mader², Daniel Lévesque³

Affiliations

¹ Faculté de Pharmacie, Université de Montréal, Montréal, QC, Canada; Institut de Recherche en Immunologie et Cancérologie (IRIC) and Département de biochimie et de médecine moléculaire, Faculté de médecine, Université de Montréal, Montréal, QC, Canada. Electronic address: fatema.dodat@umontreal.ca.
² Institut de Recherche en Immunologie et Cancérologie (IRIC) and Département de biochimie et de médecine moléculaire, Faculté de médecine, Université de Montréal, Montréal, QC, Canada.
³ Faculté de Pharmacie, Université de Montréal, Montréal, QC, Canada.

PMID: 34437889
DOI: 10.1016/j.jmb.2021.167212

Abstract

NR4A receptors, including NUR77 (NR4A1), NURR1 (NR4A2) and NOR-1 (NR4A3), form a family of nuclear receptors that act as transcription factors to regulate many physiological and pathological processes such as cell cycle and apoptosis, lipid metabolism, inflammation, carcinogenesis, vascular and neuronal functions. In the absence of known endogenous ligand modulating their physiological functions, the NR4A family remains a class of orphan receptors. However, several post-translational modifications (PTMs), including SUMOylation, have been shown to regulate the expression and/or activity of these receptors. Addition of Small Ubiquitin-like MOdifier (SUMO) proteins is a dynamic and reversible enzymatic process that regulates multiple essential functions of proteins, including nuclear receptors. This review aims at summarizing what is known about the impact of SUMOylation on NR4A family member transcriptional activities and physiological functions.

Keywords: NOR-1; NUR77; NURR1; Small Ubiquitin-like MOdifier protein; post-translational modification.

Publication types

Review

MeSH terms

Animals
Apoptosis / genetics
Carcinogenesis / genetics
Carcinogenesis / metabolism
Carcinogenesis / pathology
Cell Cycle / genetics*
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Eukaryotic Cells / cytology
Eukaryotic Cells / metabolism
Humans
Inflammation
Lipid Metabolism / genetics
Multigene Family
Nuclear Receptor Subfamily 4, Group A, Member 1 / genetics
Nuclear Receptor Subfamily 4, Group A, Member 1 / metabolism*
Nuclear Receptor Subfamily 4, Group A, Member 2 / genetics
Nuclear Receptor Subfamily 4, Group A, Member 2 / metabolism*
Protein Processing, Post-Translational*
Receptors, Steroid / genetics
Receptors, Steroid / metabolism*
Receptors, Thyroid Hormone / genetics
Receptors, Thyroid Hormone / metabolism*
Small Ubiquitin-Related Modifier Proteins / genetics
Small Ubiquitin-Related Modifier Proteins / metabolism*
Sumoylation
Transcription, Genetic

Substances

DNA-Binding Proteins
NR4A1 protein, human
NR4A2 protein, human
NR4A3 protein, human
Nuclear Receptor Subfamily 4, Group A, Member 1
Nuclear Receptor Subfamily 4, Group A, Member 2
Receptors, Steroid
Receptors, Thyroid Hormone
Small Ubiquitin-Related Modifier Proteins