EPAS1 (Endothelial PAS Domain Protein 1) Orchestrates Transactivation of Endothelial ICAM1 (Intercellular Adhesion Molecule 1) by Small Nucleolar RNA Host Gene 5 (SNHG5) to Promote Hypoxic Pulmonary Hypertension

Shouxian Wang; Yu Wang; Chang Liu; Gang Xu; Wenxiang Gao; Jiale Hao; Mengjie Zhang; Gang Wu; Yidong Yang; Jian Huang; Bing Ni; Dewei Chen; Yuqi Gao

doi:10.1161/HYPERTENSIONAHA.121.16949

EPAS1 (Endothelial PAS Domain Protein 1) Orchestrates Transactivation of Endothelial ICAM1 (Intercellular Adhesion Molecule 1) by Small Nucleolar RNA Host Gene 5 (SNHG5) to Promote Hypoxic Pulmonary Hypertension

Hypertension. 2021 Sep;78(4):1080-1091. doi: 10.1161/HYPERTENSIONAHA.121.16949. Epub 2021 Aug 30.

Authors

Shouxian Wang^{1

2

3}, Yu Wang^{1

2

3}, Chang Liu^{1

2

3}, Gang Xu^{1

3}, Wenxiang Gao^{1

2

3}, Jiale Hao^{1

2

3}, Mengjie Zhang^{4

2

3}, Gang Wu^{1

2

3}, Yidong Yang^{5

2

3}, Jian Huang^{5

2

3}, Bing Ni^{4

2

3}, Dewei Chen^{4

2

3}, Yuqi Gao^{1

2

3}

Affiliations

¹ Institute of Medicine and Equipment for High Altitude Region (S.W., Y.W., C.L., G.X., W.G., J. Hao, G.W., Y.G.), College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
² Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Chongqing (S.W., Y.W., C.L., W.G., J. Hao, M.Z., G.W., Y.Y., J. Huang, B.N., D.C., Y.G.).
³ Key Laboratory of High Altitude Medicine, PLA, Chongqing, China (S.W., Y.W., C.L., G.X., W.G., J. Hao, M.Z., G.W., Y.Y., J. Huang, B.N., D.C., Y.G.).
⁴ Department of Pathophysiology (M.Z., B.N., D.C.), College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, China.
⁵ Department of High Altitude Physiology and Pathology (Y.Y., J. Huang), College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, China.

PMID: 34455812
DOI: 10.1161/HYPERTENSIONAHA.121.16949

Abstract

[Figure: see text].

Keywords: endothelial cell; hypertension; hypoxia; mice; pulmonary; vascular remodeling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / physiology*
Humans
Hypertension, Pulmonary / etiology*
Hypoxia / complications*
Indans / pharmacology
Intercellular Adhesion Molecule-1 / genetics*
Male
Mice
Mice, Inbred C57BL
MicroRNAs / physiology
RNA, Small Nucleolar / physiology*
Sulfones / pharmacology
Transcriptional Activation*

Substances

Basic Helix-Loop-Helix Transcription Factors
Icam1 protein, mouse
Indans
MIRN625 microRNA, mouse
MicroRNAs
PT2385
RNA, Small Nucleolar
Sulfones
Intercellular Adhesion Molecule-1
endothelial PAS domain-containing protein 1