Vaginal NOTES approach for risk-reducing salpingo-oophorectomy in BRCA mutation carriers: A video demonstration

J Gynecol Obstet Hum Reprod. 2021 Dec;50(10):102212. doi: 10.1016/j.jogoh.2021.102212. Epub 2021 Sep 2.

Abstract

Risk-reducing bilateral salpingo-oophorectomy (BSO) is an important option to prevent the development of ovarian and fallopian tube cancers in women with a BRCA1/2 mutation. Conventional laparoscopy is the current preferred technique since it is associated with less morbidity compared to laparotomy. Transvaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) is a new minimally invasive technique that allows access to the peritoneal cavity through the vagina without skin incisions. The vNOTES technique for risk-reducing BSO is presented herein. This article includes a narrated, step-by-step video demonstration of the entire procedure. Risk-reducing BSO using the vNOTES approach is a feasible technique that appears to be simple, safe, and reproducible. This technique has the potential to improve patients' surgical experience and provide good long-term functional and cosmetics outcomes. This technique needs to be further evaluated and compared to the conventional laparoscopic approach.

Keywords: BRCA; Bilateral salpingo-oophorectomy; Natural orifice transluminal endoscopic surgery; Risk reducing surgery; Surgical education; vNOTES technique.

Publication types

  • Case Reports

MeSH terms

  • BRCA1 Protein / analysis*
  • BRCA1 Protein / genetics
  • BRCA2 Protein / analysis*
  • BRCA2 Protein / genetics
  • Female
  • Heterozygote
  • Humans
  • Middle Aged
  • Risk Reduction Behavior
  • Salpingo-oophorectomy / methods
  • Salpingo-oophorectomy / standards*
  • Salpingo-oophorectomy / statistics & numerical data

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human